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FibroScan®

Published Studies

The following is a selection of articles on FibroScan and CAP published by the different gastroenterologists and hepatologists of Canada and abroad. More articles on FibroScan and CAP may be found online through PubMed , bmjjournals, MDLink or at the Echosens Library.
1) Alcoholic Fatty Liver Disease

Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation (2012)

Association of Liver Stiffness with Hepatic Expression of Pharmacokinetically Important Genes in Alcoholic Liver Disease (2012)

Rapid Decline of Liver Stiffness Following Alcohol Withdrawal in Heavy Drinkers (2012)

 

2) Amyloidosis

Non-invasive detection of hepatic amyloidosis: FibroScan, a new tool (2011)

 

3) ARFI vs FibroScan

ARFI, FibroScan®, ELF, and their combinations in the assessment of liver fibrosis: A prospective study (2011)

Evaluation of liver fibrosis by transient elastography using acoustic radiation force impulse: comparison with Fibroscan (2013)

Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis (2011)

Fibroscan for assessing liver fibrosis: An acceptable alternative for liver biopsy (2011)

Comparison of Transient Elastography and Acoustic Radiation Force Impulse for Non-Invasive Staging of Liver Fibrosis in Patients With Chronic Hepatitis C (2011)

Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation (2011)

 

4) Biliary Atresia

Transient elastography for predicting esophageal/gastric varices in children with biliary atresia (2011)

Serum adiponectin and transient elastography as non-invasive markers for postoperative biliary atresia (2011)

Correlation of connective tissue growth factor with liver stiffness measured by transient elastography in biliary atresia (2013)

 

5) Biliary Cirrhosis

Noninvasive elastography-based assessment of liver fibrosis progression and prognosis in primary biliary cirrhosis (2012)

Performance and utility of transient elastography and noninvasive markers of liver fibrosis in primary biliary cirrhosis (2011)

 

6) Canadian Studies

Liver Stiffness by Transient Elastography Predicts Liver- Related Complications and Mortality in Patients with Chronic Liver Disease (2014)

Liver stiffness by transient elastography predicts liver-related complications and mortality in patients with chronic liver disease (2014)

Physicians’ practices for diagnosing liver fibrosis in chronic liver diseases: a nationwide, Canadian survey. (2014)

 

7) Celiac Disease

Transient elastography in patients with celiac disease: A noninvasive method to detect liver involvement associated with celiac disease (2012)

 

8) Chronic Liver Disease
Transient elastography in chronic viral hepatitis: a critical appraisal (2012)

Current status of novel antifibrotic therapies in patients with chronic liver disease (2011)

The accuracy of noninvasive methods in the prediction of clinically relevant outcomes in patients with chronic liver disease (2011)

Diffusion-weighted MRI versus transient elastography in quantification of liver fibrosis in patients with chronic cholestatic liver diseases (2012)

Development and evaluation of a nurse-led transient elastography service for the staging of hepatic fibrosis in patients with suspected chronic liver disease (2012)

 

9) Cirrhosis and Portal Hypertension

Elastography, Spleen Size, and Platelet Count Identify Portal Hypertension in Patients With Compensated Cirrhosis (2012)

Transient Elastography and Prognosis of Cirrhosis (2012)

Role of hepatic vein catheterisation and transient elastography in the diagnosis of idiopathic portal hypertension (2012)

Transient elastography: a meta-analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease (2013)

Liver elastography for the diagnosis of portal hypertension in patients with liver cirrhosis (2012)

Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis (2012)

Transient elastography and simple blood markers in the diagnosis of esophageal varices for compensated patients with hepatitis B virus-related cirrhosis (2012)

Liver stiffness measurement in cirrhotic patient – Implications of disease activity and treatment efficacy (2012)

 

10) Critical Care

Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU (2011)

 

11) Cystic Fibrosis

Non-Invasive Evaluation of Cystic Fibrosis Related Liver Disease in Adults with ARFI, Transient Elastography and Different Fibrosis Scores (2012)

 

12) Diabetes

A prospective evaluation of the role of transient elastography for the detection of hepatic fibrosis in type 2 diabetes without overt liver disease (2012)

Screening for liver fibrosis by using FibroScan® and FibroTest in patients with diabetes (2012)

 

13) Pediatrics

Transient elastography for predicting esophageal/gastric varices in children with biliary atresia (2011)

Feasibility study and control values of transient elastography in healthy children (2011)

Assessment of liver stiffness with transient elastography by using S and M probes in healthy children (2012)

The Utility of Transient Elastography to Assess for Hepatic Fibrosis in Pediatric Fontan Patients (B. Chen & R.A. Schreiber, 2012)

Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection (2011)

Transient elastography and portal hypertension in pediatric patients with cystic fibrosis Transient elastography and cystic fibrosis (2011)

Accuracy and Reproducibility of Transient Elastography for the Diagnosis of Fibrosis in Pediatric Nonalcoholic Steatohepatitis (2008)

 

14) Haemophilia

Previously unrecognized advanced liver disease unveiled by transient elastography in patients with Haemophilia and chronic hepatitis C (2011)

 

15) Hepatocellular Carcinoma

Does transient elastography (FibroScan®) have a role in decision making in hepatocellular carcinoma? (2012)

 

16) Heart Failure

Impact of heart failure and changes to volume status on liver stiffness: non-invasive assessment using transient elastography (2012)

 

17) Hepatic Surgery

Value of Transient Elastography Measured With Fibroscan in Predicting the Outcome of Hepatic Resection for Hepatocellular Carcinoma (2012)

Prediction of Recurrence after Curative Resection of Hepatocellular Carcinoma using Liver Stiffness Measurement (FibroScan) (2012)

Assessment of Liver Stiffness Measurement: Novel Intraoperative Blood Loss Predictor? (2013)

 

18) Hepatitis B

Improving transient elastography performance for detecting hepatitis B cirrhosis (2011)

Performance of Transient Elastography for the Staging of Liver Fibrosis in Patients with Chronic Hepatitis B: A Meta-Analysis (2012)

Noninvasive Measurement of Liver Fibrosis by Transient Elastography and Influencing Factors in Patients with Chronic Hepatitis B―A Single Center Retrospective Study of 466 Patients* (2012)

The role of transient elastography in patients with hepatitis B viral disease (2011)

The use of transient elastography in the management of chronic hepatitis B (2011)

Prospective Validation of ELF Test in Comparison with Fibroscan and FibroTest to Predict Liver Fibrosis in Asian Subjects with Chronic Hepatitis B (2012)

Can transient elastography be used for the management of chronic hepatitis B patients? (2012)

Diagnostic accuracy of transient elastography (FibroScan) versus the aspartate transaminase to platelet ratio index in assessing liver fibrosis in chronic hepatitis B: The role in primary care setting (2011)

Liver Stiffness Measurement and Biochemical Markers in Senegalese Chronic Hepatitis B Patients with Normal ALT and High Viral Load (2011)

Longitudinal assessment of liver stiffness by transient elastography for chronic hepatitis B patients treated with nucleoside analog (2011)

The effect of caffeine and alcohol consumption on liver fibrosis – a study of 1045 Asian hepatitis B patients using transient elastography (2011)

Reduction of liver stiffness by antiviral therapy in chronic hepatitis B (2011)

Elastography for Hepatic Fibrosis Severity in Chronic Hepatitis B or C (2011)

Optimal Time for Restoring the Reliability of Liver Stiffness Measurement in Patients With Chronic Hepatitis B Experiencing Acute Exacerbation (2012)

Noninvasive Markers of Hepatic Fibrosis in Chronic Hepatitis B (2011)

Impact of mild to moderate elevations of alanine aminotransferase on liver stiffness measurement in chronic hepatitis B patients during antiviral therapy (2012)

 

19) Hepatitis C

A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation (2011)

Liver stiffness measured by transient elastography is a predictor of hepatocellular carcinoma development in viral hepatitis (2011)

Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: a clinical study on 113 hepatitis C virus patients (2011)

A New Combination of Blood Test and Fibroscan for Accurate Non-Invasive Diagnosis of Liver Fibrosis Stages in Chronic Hepatitis C (2011)

Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C (2011)

Noninvasive Methods to Assess Liver Disease in Patients With Hepatitis B or C (2012)

Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B 2 virus infected patients with different ALT levels (2012)

Performance of Real-Time Strain Elastography, Transient Elastography, and Aspartate-to- Platelet Ratio Index in the Assessment of Fibrosis in Chronic Hepatitis C (2012)

Liver stiffness diminishes with antiviral response in chronic hepatitis C (2011)

Staging Liver Fibrosis in Hepatitis C: A Challenge for This Decade (2011)

Longitudinal Liver Stiffness Assessment in Patients with Chronic Hepatitis C Undergoing Antiviral Therapy (2012)

Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography (2012)

Previously unrecognized advanced liver disease unveiled by transient elastography in patients with Haemophilia and chronic hepatitis C (2011)

Elastography for Hepatic Fibrosis Severity in Chronic Hepatitis B or C (2011)

FibroSURE™ and FibroScan® in relation to treatment response in chronic hepatitis C virus (2011)

FibroTest® and Fibroscan® performances revisited in patients with chronic hepatitis C. Impact of the spectrum effect and the applicability rate (2011)

Performances of Elasto-FibroTest®, a combination between FibroTest® and liver stiffness measurements for assessing the stage of liver fibrosis in patients with chronic hepatitis C (2012)

Levels of Alanine Aminotransferase Confound Use of Transient Elastography to Diagnose Fibrosis in Patients With Chronic Hepatitis C Virus Infection (2012)

 

20) HIV & Hepatitis C Coinfection

Course of Liver Fibrosis in HIV-Hepatitis C Virus-Coinfected Patients Depending on the Response to Hepatitis C Therapy (2013)

Non-cirrhotic portal hypertension in HIV mono-infected patients (2012)

Prospective evaluation of hepatic steatosis in HIV-infected patients with or without hepatitis C virus co-infection (2012)

Liver Stiffness Predicts Clinical Outcome in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Patients With Compensated Liver Cirrhosis (2012)

A prospective evaluation of pulmonary, systemic and hepatic haemodynamics in HIV–HCV-coinfected patients before and after antiviral therapy with pegylated interferon and ribavirin (2012)

Coinfection by human immunodeficiency virus and hepatitis C virus: noninvasive assessment and staging of fibrosis (2012)

Didanosine (ddI) associates with increased liver fibrosis in adult HIV–HCV coinfected patients (2012)

 

21) Iron Overload

Diagnosis of liver fibrosis using FibroScan and other noninvasive methods in patients with hemochromatosis: A prospective study (2008)

Non-invasive methods for liver fibrosis prediction in hemochromatosis: One step beyond (2010)

Liver fibrosis in young Egyptian beta-thalassemia major patients: relation to hepatitis C virus and compliance with chelation. (2013)

Transient elastography in the assessment of liver fibrosis in adult thalassemia patients (2010)

Non-invasive assessment of liver fibrosis by transient elastography in post transfusional iron overload (2008)

 

22) Meta Analysis

Ultrasound-Based Transient Elastography for the Detection of Hepatic Fibrosis in Patients With Recurrent Hepatitis C Virus After Liver Transplantation: A Systematic Review and Meta-Analysis (2012)

Performance of Transient Elastography for the Staging of Liver Fibrosis in Patients with Chronic Hepatitis B: A Meta-Analysis (2012)

Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis (2008)

FibroTest and FibroScan for the Prediction of Hepatitis C-Related Fibrosis: A Systematic Review of Diagnostic Test Accuracy (2007)

Transient elastography: a meta-analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease (2012)

A health technology assessment of transient elastography in adult liver disease (2013)

 

23) NAFLD

Transient Elastography for Assessment of Non-Alcoholic Fatty Liver Disease (2011)

Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease (2012)

Review article: the diagnosis of non-alcoholic fatty liver disease – availability and accuracy of non-invasive methods (2012)

Liver Stiffness Measurements in Patients with Different Stages of Nonalcoholic Fatty Liver Disease: Diagnostic Performance and Clinicopathological Correlation (2012)

Assessment by Fibroscan of Fibrosis in Nonalcoholic Fatty Liver Disease: XL Versus M Probe? (2012)

Reliability of liver stiffness measurement in non-alcoholic fatty liver disease: the effects of body mass index (2011)

Liver Stiffness Measurement Using XL Probe in Patients With Nonalcoholic Fatty Liver Disease (2012)

 

24) Methotrexate

Evaluation of liver fibrosis by transient elastography (Fibroscan ) in patients with inflammatory bowel disease treated with methotrexate: a multicentric trial (2012)

Evaluation of liver fibrosis by transient elastography in methotrexate treated patients (2011)

Diagnosis of liver fibrosis by transient elastography (FibroScan) and non-invasive methods in Crohn’s disease patients treated with methotrexate (2006)

Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate (2012)

Liver injury in long-term methotrexate treatment in psoriasis is relatively infrequent (2006)

Assessment of liver fibrosis by transient elastography in rheumatoid arthritis patients treated with methotrexate (2010)

 

25) Spleen Stiffness and Cirrhosis

Spleen Stiffness Measured by Transient Elastography Accurately Predicts Esophageal Varices in Liver Cirrhosis (2012)

 

26) Wilson’s Disease

Non-invasive assessment of hepatic fibrosis in a series of patients with Wilson’s Disease (2012)

 

27) XL Probe

Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients (2011)

 

FibroMeter Studies

Improved fibrosis staging by elastometry and blood test in chronic hepatitis C

The combination of a blood test and FibroScan improves the non-invasive diagnosis of liver fibrosis

Comparison of Eight Diagnostic Algorithms for Liver Fibrosis in Hepatitis C: New Algorithms Are More Precise and Entirely Noninvasive

A New Combination of Blood Test and FibroScan for Accurate Non-Invasive Diagnosis of Liver Fibrosis Stages in Chronic Hepatitis C

Diagnostic usefulness of FibroMeter VCTE for hepatic fibrosis in patients with nonalcoholic fatty liver disease

AASLD: “When and in whom to initiate HCV Therapy”